Key result
Starr-Edwards mitral valve requires explantation after 15 years due to late hemodynamic gradient.
Why the study?
Early-generation mechanical mitral valve prostheses like the Starr-Edwards caged-ball valve demonstrate remarkable durability but have long-term risks including thromboembolic complications and pannus formation causing gradients.
Case Report (n=1)
This case highlights the remarkable structural durability of early-generation Starr-Edwards caged-ball valves, which may still be encountered in clinical practice and require replacement due to pannus formation rather than structural failure.
Legacy caged-ball MV prostheses persist in survivors; Level 5 data leaves open optimal long-term anticoagulation and monitoring.
Mechanical mitral valve (MV) prostheses have evolved considerably over the past few decades, with early designs still being seen in patients because of their proven durability. Although these early-generation valves like the caged-ball prosthesis demonstrated remarkable longevity, their long-term use was eventually limited by the risk of thromboembolic complications and gradual development of gradients due to pannus formation. Despite discontinuation of their manufacture, such valves continue to be encountered in current clinical practice due to their extensive historical implantation. In this report, we discuss a case of a 30-year-old female who underwent an MV replacement with a Starr-Edwards (SE) caged-ball valve prosthesis 15 years back and had now come with a significant gradient. This case highlights the durability of the SE valve and how the need for later replacement is not due to a structural issue of the valve.
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Sarkar et al. (2026) conducted a case report in Mitral valve prosthesis with significant gradient (n=1). Starr-Edwards caged-ball mitral valve prosthesis was evaluated. A Starr-Edwards caged-ball mitral valve prosthesis required explantation 15 years post-implantation due to a significant gradient rather than structural valve failure in a 30-year-old female.
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