Key result
Infections occur in ~4% of neonates on VA-ECMO and are linked to higher mortality.
Why the study?
The incidence, risk factors, and impact of bacterial and fungal infections in neonates undergoing VA ECMO were not fully characterized.
Population
5,001 neonatal VA ECMO cases
Comparison
Infected versus non-infected neonates; bacterial versus fungal infections
Design
Observational registry data analysis
Authors
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Infection incidence informs ECMO surveillance protocols; leaves open modifiable risk factors for prospective validation.
Observational (n=5,001)
Yes
Douglass et al. (1996) conducted an observational in Neonates undergoing venoarterial extracorporeal membrane oxygenation (n=5,001). Bacterial and fungal infection vs. No infection was evaluated on Overall incidence of bacterial and fungal infection. Bacterial and fungal infections occurred in 3.5% of neonates undergoing venoarterial ECMO and were associated with significantly longer bypass duration and higher hospital mortality.
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