Key result
Adding quercetin to bisoprolol increases complete suppression of ventricular ectopy to ~55% in postinfarction cardiosclerosis.
Why the study?
Abnormal cardiac rhythms and life-threatening ventricular ectopy in postinfarction cardiosclerosis require optimized treatment strategies to prevent sudden cardiac death.
May guide therapy optimization in post-MI patients with HRT; leaves open confirmation in prospective trials.
The objective of the research was to optimize treatment of patients with ischemic heart disease (postinfarction cardiosclerosis) and concomitant phenomenon of heart rate turbulence based on the study of heart rate turbulence and heart rate variability.Materials and methods. The study included 100 patients with ischemic heart disease and postinfarction cardiosclerosis complicated by cardiac rhythm disorder (ventricular ectopic beats). Patients were divided into 2 groups according to the type of prophylaxis: Group I received bisoprolol; Group II received quercetin in addition to bisoprolol. A daily dose of bisoprolol was 0.07 mg/kg body weight while a daily dose of quercetin was 1g for 7 days. The control of therapy effectiveness was performed using Holter monitoring of heart rate turbulence and heart rate variability.Results. Bisoprolol intake by patients with ischemic heart disease and concomitant heart rate turbulence led to significant increase in the stress index as well as the decrease in the overall tension of body regulation, either parasympathetic or sympathetic divisions of the autonomic nervous system and the vasomotor center. Drug intake did not lead to the abnormal physiological correlation between the activity of the subcortical and peripheral components of the nervous systems. While analyzing the changes in the indices of heart rate turbulence and heart rate variability, there was found, that during combination treatment of patients with ischemic heart disease using bisoprolol and quercetin, positive changes appeared in the regulatory parts of the body.Conclusions. Combination treatment of post-myocardial infarction patients with bisoprolol and quercetin allows us: a) to achieve complete reduction in ventricular ectopic activity in more than half of patients; b) to reduce the number of patients with life-threatening ventricular ectopic beats significantly; c) to maintain the physiological value and the activity of the autonomic nervous system as well as the vasomotor center of the body; d) to decrease the level of turbulence onset and maintain the value of turbulence slope.
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A I Vytryhovskiy (2016) studied Ischemic heart disease and postinfarction cardiosclerosis with ventricular ectopic beats (n=100). Bisoprolol and Quercetin vs. Bisoprolol alone was evaluated on Complete reduction in ventricular ectopic activity. Combination treatment with bisoprolol and quercetin achieved complete reduction in ventricular ectopic activity in 54.54% of patients compared to 11.11% with bisoprolol alone in patients with postinfarction cardiosclerosis.
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