Key result
Distinct macrophage subsets drive both the development and resolution of myocardial fibrosis.
Why the study?
The roles of different macrophage populations in myocardial fibrosis have not yet been extensively investigated compared to other organ fibroses.
Design
Review article
Authors
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Hypothesis-generating for macrophage-targeted antifibrotic therapies; leaves open clinical translation pending interventional studies.
Yamate et al. (1999) conducted a review in Myocardial fibrosis. Macrophage populations was evaluated. Macrophage populations, including exudate macrophages, resident macrophages, and interstitial dendritic cells, play central roles in the development and resolution of myocardial fibrosis.
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