Key result
Single-breath-hold 3D-QALAS enables whole-LV T1 and T2 mapping with near-perfect phantom accuracy.
Why the study?
Current cardiac relaxation time mapping methods require long breath holds and measure either T1 or T2 in a single 2D slice, limiting clinical applicability.
Observational
No
Effect estimate: R = 0.999 for T1, R = 0.960 for T2
Background Quantification of the longitudinaland transverse relaxation time in the myocardium has shown to provide important information in cardiac diagnostics. Several methods are currently available for cardiac relaxation time mapping but they generally demand a long breath hold to measure either T1 or T2 in a single 2D slice. In order to make quantification of relaxation parameters in the myocardium clinically applicable, the methods must be improved in speed and coverage. In this work we propose a novel method for 3D interleaved T1 and T2 quantification of the whole left ventricular myocardium within one single breath hold.
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Kvernby et al. (2014) conducted an observational in Healthy volunteers and phantoms. 3D-QALAS MRI sequence vs. Reference methods (Inversion Recovery for T1, Multi Echo for T2) was evaluated on Correlation of relaxation times with reference methods in phantoms (R = 0.999 for T1, R = 0.960 for T2). The 3D-QALAS sequence allowed quantification of both T1 and T2 in the whole left ventricular myocardium within a single breath hold, showing excellent correlation with reference methods in phantoms.
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