Key result
Yohimbine raises the arrhythmogenic dose of epinephrine by ~25% versus xylazine alone.
Why the study?
The effects of xylazine and subsequent yohimbine administration on epinephrine-induced arrhythmogenesis in isoflurane-anesthetized dogs were evaluated to understand their impact on arrhythmogenic dose.
Absolute Event Rate: 45.7% vs 36.6%
p-value: p=< 0.05
Yohimbine may attenuate xylazine-enhanced epinephrine arrhythmogenicity in isoflurane-anesthetized dogs; leaves open translation to clinical veterinary practice.
Effects of xylazine (1.1 mg/kg of body weight, IV bolus, plus 1.1 mg/kg/h infusion) and subsequent yohimbine (0.125 mg/kg, IV bolus) administration on the arrhythmogenic dose of epinephrine (ADE) in isoflurane (1.8% end-tidal)-anesthetized dogs were evaluated. The ADE was defined as the total dose of epinephrine that induced greater than or equal to 4 premature ventricular contractions within 15 seconds during a 3-minute infusion period or within 1 minute after the end of infusion. Total ADE values during isoflurane anesthesia, after xylazine administration, and after yohimbine injection were 36.6 +/- 8.45 micrograms/kg, 24.1 +/- 6.10 micrograms/kg, and 45.7 +/- 6.19 micrograms/kg, respectively. Intravenous xylazine administration significantly (P less than 0.05) increased blood pressure and decreased heart rate, whereas yohimbine administration induced a significant (P less than 0.05) decrease in blood pressure. induced a significant (P less than 0.05) decrease in blood pressure. After yohimbine administration, the ADE significantly (P less than 0.05) increased above that after isoflurane plus xylazine administration. After yohimbine administration, blood pressure measured immediately before epinephrine-induced arrhythmia was significantly (P less than 0.05) less than the value recorded during isoflurane plus xylazine anesthesia. Heart rate was unchanged among treatments immediately before epinephrine-induced arrhythmia. Seemingly, yohimbine possessed a protective action against catecholamine-induced arrhythmias in dogs anesthetized with isoflurane and xylazine.
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Tranquilli et al. (1988) studied Isoflurane-anesthetized dogs. Xylazine and subsequent yohimbine vs. Isoflurane anesthesia alone was evaluated on Arrhythmogenic dose of epinephrine (ADE) (p=< 0.05). In isoflurane-anesthetized dogs, yohimbine administration significantly increased the arrhythmogenic dose of epinephrine to 45.7 +/- 6.19 micrograms/kg compared to xylazine alone (P < 0.05).
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