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November 1, 1993AnesthesiologyOpen Access

Arrbythmogenic Doses of Epinephrine Are Similar during Desflurane or Isoflurane Anesthesia in Humans

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Why the study?

Does desflurane compared to isoflurane alter the arrhythmogenicity of exogenously administered epinephrine in patients undergoing transsphenoidal resection of pituitary tumors?

Population

36 ASA physical status 1 and 2 patients undergoing transsphenoidal resection of pituitary tumors

Comparison

1.0-1.3 MAC desflurane anesthesia with… vs 1.0-1.3 MAC isoflurane anesthesia with…

Design

RCT, randomly assigned, surgeon blinded to the administered anesthetic and the…

Follow-up

5 min after starting the injection

Authors

MMMark A. MooreLifenet HealthRWRichard B. WeiskopfCross-Cutting CardiologyEEEdmond I. EgerUniversity of Central Florida

Discussion

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Implication

Desflurane does not increase epinephrine arrhythmogenicity versus isoflurane; confirms equivalent myocardial sensitization and supports interchangeable use.

Structured PICO

Does desflurane compared to isoflurane alter the arrhythmogenicity of exogenously administered epinephrine in patients undergoing transsphenoidal resection of pituitary tumors?

P
Population
36 ASA physical status 1 and 2 patients undergoing transsphenoidal resection of pituitary tumors
I
Intervention
1.0-1.3 MAC desflurane anesthesia with submucosally administered epinephrine (1:50,000, 1:75,000, or 1:100,000)
C
Comparator
1.0-1.3 MAC isoflurane anesthesia with submucosally administered epinephrine
O
Outcome
Positive response defined as three or more premature ventricular contractions (PVCs) in the 5 min after starting the injectionsafety

Isoflurane and desflurane do not differ in their sensitization of human myocardium to the arrhythmogenic effects of exogenously administered epinephrine.

Cite This Study

Moore et al. (1993) studied this question.

synapsesocial.com/papers/6a82bb6ffb68d755121c23c8https://doi.org/10.1097/00000542-199311000-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Humans Anesthetized with Sevoflurane or Isoflurane Have Similar Arrhythmic Response to Epinephrine1994 · 97 citations
  2. 2A Comparative Interaction of Epinephrine with Enflurane, Isoflurane, and Halothane in Man1976 · 282 citations
  3. 3Effect of Epinephrine During Enflurane Anesthesia1974 · 6 citations
  4. 4Ventricular Arrhythmias after Epinephrine Injection in Enflurane and in Halothane Anesthesia1975 · 25 citations
  5. 5Comparison of heart rate response to an epinephrine test dose and painful stimulus in children during sevoflurane anesthesia: heart rate variability and beat-to-beat analysis2003 · 13 citations