Key result
Subcutaneous epinephrine shows no link to ventricular arrhythmias during enflurane anesthesia.
Why the study?
The arrhythmogenic properties of subcutaneously administered epinephrine in clinical doses under enflurane anesthesia were not well characterized.
Does subcutaneously administered epinephrine cause ventricular arrhythmias in patients under enflurane anesthesia?
Population
300 patients under enflurane anesthesia
Comparison
Epinephrine with or without lidocaine vs no epinephrine
Design
Observational study
Follow-up
During anesthesia
Authors
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May support continued use of subcutaneous epinephrine with enflurane; leaves open randomized confirmation of safety.
Observational (n=300)
Does subcutaneously administered epinephrine cause ventricular arrhythmias in patients under enflurane anesthesia?
Subcutaneous epinephrine administration during enflurane anesthesia does not appear to increase the risk of ventricular arrhythmias.
Konchigeri et al. (1974) conducted an observational in Enflurane anesthesia (n=300). Subcutaneously administered epinephrine was evaluated on Ventricular arrhythmias (isolated premature ventricular contractions). Subcutaneously administered epinephrine during enflurane anesthesia was unrelated to ventricular arrhythmias in 300 patients.
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