Key result
Intravenous practolol and metoprolol were effective and safe for treating sinus tachycardia and ventricular dysrhythmias during enflurane dental anaesthesia.
Why the study?
Do intravenous practolol and metoprolol effectively treat sinus tachycardia and ventricular dysrhythmias during outpatient dental anaesthesia with enflurane?
Observational (n=120)
Do intravenous practolol and metoprolol effectively treat sinus tachycardia and ventricular dysrhythmias during outpatient dental anaesthesia with enflurane?
Intravenous practolol and metoprolol are effective and safe for treating sinus tachycardia and ventricular dysrhythmias during enflurane dental anaesthesia.
May support beta-blockers for arrhythmias in enflurane anaesthesia; leaves open randomized confirmation before practice change.
In a study of 120 unpremedicated outpatients presenting for outpatient dental anaesthesia, the incidence of dysrhythmias was lower with enflurane than had previously been found with halothane (1). The intravenous use of the cardioselective beta adrenergic blocking agents practolol and metoprolol, in a dose of 0.05-0.22 and 0.16-0.17 mg/kg body weight, respectively, proved effective in the treatment of sinus tachycardia in excess of 150 beats/min and/or ventricular dysrhythmias. Although metoprolol, unlike practolol, has no intrinsic sympathetic activity, there were no side-effects related to either beta-blocker in the dosages used during enflurane anaesthesia.
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Rollason et al. (1984) conducted an observational in Outpatients presenting for dental anaesthesia (n=120). Practolol and metoprolol was evaluated on Treatment of sinus tachycardia >150 beats/min and/or ventricular dysrhythmias. Intravenous practolol and metoprolol were effective and safe for treating sinus tachycardia and ventricular dysrhythmias during enflurane dental anaesthesia.
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