Key result
Enflurane shows no difference vs. isoflurane for cardiac dysrhythmias during third molar surgery.
Why the study?
The incidence and nature of cardiac dysrhythmias during enflurane and isoflurane anaesthesia for dental surgery were compared due to limited direct comparative data.
Does enflurane compared to isoflurane affect the incidence of cardiac dysrhythmias in healthy young adults undergoing dental surgery?
RCT (n=76)
Randomized
Does enflurane compared to isoflurane affect the incidence of cardiac dysrhythmias in healthy young adults undergoing dental surgery?
Both enflurane and isoflurane are associated with a low and comparable incidence of cardiac dysrhythmias during dental surgery in healthy young adults.
Answers are grounded in this paper and cite their sources.
Either agent is acceptable for dental anesthesia; confirms comparable arrhythmia safety with enflurane versus isoflurane in young adults.
The incidence and nature of dysrhythmias with equipotent concentrations of enflurane and isoflurane during dental surgery were compared. Seventy-six Chinese patients between 17-30 years, of ASA Grade I, randomly received either enflurane or isoflurane with N2O and O2 for spontaneous ventilation during third molar extractions. The cardiac rhythm and the blood pressure were continuously monitored during the procedure. The incidence of dysrhythmias with both enflurane and isoflurane was low and the difference not statistically significant. During surgery one patient exhibited unifocal ventricular ectopics with isoflurane. Sinus tachycardia was common with both agents. No life-threatening dysrhythmias were seen with either agent and no clinically significant lowering of blood pressure occurred in association with the exhibited dysrhythmias. In this Chinese population, as in other studies, the incidence of dysrhythmias with both agents was low thus showing no difference between the races.
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Rodrigo et al. (1987) conducted an RCT in Dental surgery (third molar extractions) (n=76). Enflurane vs. Isoflurane was evaluated on incidence and nature of dysrhythmias (p=not statistically significant). Enflurane and isoflurane anesthesia resulted in a similarly low incidence of cardiac dysrhythmias during third molar extractions, with no statistically significant difference between the agents.
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