Key result
Isoflurane results in 0 ventricular dysrhythmias versus halothane during dental extraction anesthesia.
Why the study?
The comparative effects of isoflurane and halothane on cardiac dysrhythmias during dental general anaesthesia were unclear.
Does isoflurane reduce the incidence of cardiac dysrhythmias compared to halothane in dental outpatients having extractions under general anaesthesia?
RCT (n=100)
Single-blind
Randomized
Does isoflurane reduce the incidence of cardiac dysrhythmias compared to halothane in dental outpatients having extractions under general anaesthesia?
p-value: p=0.0013
Isoflurane significantly reduces the incidence of ventricular dysrhythmias compared to halothane during general anesthesia for dental extractions.
Isoflurane may be preferred over halothane to reduce ventricular dysrhythmias in dental anaesthesia; reinforces safer volatile selection in outpatient RCTs.
A randomised single-blind trial was performed to compare the effects on cardiac rhythm of isoflurane and halothane in 100 dental outpatients having extractions under general anaesthesia in the dental chair without tracheal intubation. The incidence of supraventricular dysrhythmias did not differ significantly. No patient in the isoflurane group developed a ventricular dysrhythmia, whilst nine of those who received halothane did so (p = 0.0013). The quality of anaesthesia was acceptable in the isoflurane group, but induction time was longer (p less than 0.05) and the maximum heart rate was faster (p less than 0.01). There was no difference in the maximum end tidal carbon dioxide concentrations measured in a further 20 cases.
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Cripps et al. (1987) conducted an RCT in Dental extractions (n=100). Isoflurane vs. Halothane was evaluated on Incidence of ventricular dysrhythmias (p=0.0013). Isoflurane resulted in 0 ventricular dysrhythmias compared to 9 cases with halothane during general anaesthesia for dental extractions (p = 0.0013).
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