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March 1, 1994AnesthesiologyOpen Access

Humans Anesthetized with Sevoflurane or Isoflurane Have Similar Arrhythmic Response to Epinephrine

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Why the study?

Does sevoflurane compared to isoflurane alter the arrhythmic response to exogenously administered epinephrine in patients undergoing transsphenoidal surgery?

Population

n=40 ASA physical status 1 or 2 patients undergoing transsphenoidal surgery

Comparison

Sevoflurane with submucosal epinephrine injection vs Isoflurane with submucosal epinephrine injection

Design

RCT, assigned randomly, surgeon, blinded to the anesthetic and the…

Follow-up

5 minutes

Authors

RNRenee NavarroUniversity of California, San FranciscoRWRichard B. WeiskopfCross-Cutting CardiologyMMMark A. MooreLifenet Health

Discussion

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Implication

Sevoflurane and isoflurane show equivalent arrhythmogenic effects with high-dose epinephrine; confirms similar myocardial sensitization in this RCT population.

Structured PICO

Does sevoflurane compared to isoflurane alter the arrhythmic response to exogenously administered epinephrine in patients undergoing transsphenoidal surgery?

P
Population
n=40 ASA physical status 1 or 2 patients undergoing transsphenoidal surgery
I
Intervention
Sevoflurane (1.0-1.3 minimum alveolar concentration) with submucosal epinephrine injection (10, 13.3, or 20 micrograms/ml)
C
Comparator
Isoflurane (1.0-1.3 minimum alveolar concentration) with submucosal epinephrine injection
O
Outcome
Three or more premature ventricular contractions within 5 min after initiation of epinephrine injectionsafety

Sevoflurane and isoflurane have similar arrhythmogenic sensitization effects on the human myocardium when exogenous epinephrine is administered.

Cite This Study

Navarro et al. (1994) studied this question.

synapsesocial.com/papers/6a82bb6ffb68d755121c23c7https://doi.org/10.1097/00000542-199403000-00010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arrbythmogenic Doses of Epinephrine Are Similar during Desflurane or Isoflurane Anesthesia in Humans1993 · 66 citations
  2. 2The Effects of Sevoflurane, Isoflurane, Halothane, and Enflurane on Hemodynamic Responses During an Inhaled Induction of Anesthesia via a Mask in Humans1996 · 24 citations
  3. 3The Effects of Sevoflurane, Isoflurane, Halothane, and Enflurane on Hemodynamic Responses During an Inhaled Induction of Anesthesia via a Mask in Humans1996 · 66 citations
  4. 4Comparison of heart rate response to an epinephrine test dose and painful stimulus in children during sevoflurane anesthesia: heart rate variability and beat-to-beat analysis2003 · 13 citations
  5. 5Simulation of an Epidural Test Dose with Intravenous Epinephrine in Sevoflurane-Anesthetized Children1998 · 29 citations