Renal Regulation of Serum α-Lipoproteins

STUDIES of families have shown that absence of serum α-lipoprotein may be genetically determined.1 The importance of female sex hormones in its regulation was suggested when higher levels were observed in females than in males,2 and when increased concentrations were found in men treated with estrogen.3 When low concentrations were observed in nephrotic patients4 it was suggested the kidneys might participate in determining the level.The present study indicates a relation between kidney and α-lipoprotein levels – that is, high-density lipoproteins with electrophoretic mobility of α1-globulin. Low levels of serum α-lipoprotein were found in patients with terminal uremia, or those . . .