April 10, 1996JAMA
Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction: The TIMI III registry
Key result
Blacks and women undergo fewer invasive procedures despite similar 42-day rates of death or MI.
- n=3,318
Why the study?
The natural history and treatment response of patients with unstable angina or non-Q-wave MI according to race, sex, and age were not well characterized.
Population
3318 patients with unstable angina or non-Q-wave MI from 18 hospitals
Comparison
Black vs nonblack, women vs men, elderly (≥75 years) vs younger patients
Design
Inception cohort with prospective follow-up and specific sampling strategies
Follow-up
42 days
Authors
Discussion
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Implication
Lower procedure rates in Blacks and women were not associated with worse 42-day outcomes; leaves open whether reducing procedures is safe.
Study Design
Type
Cohort (n=3,318)
Multicenter
Yes
PICO
P
Population
3,318 patients with unstable angina or non-Q-wave MI, followed prospectively for 42 days to assess outcomes by race, sex, and age.
E
Exposure / Comparator
Race (black vs nonblack), sex (women vs men), and age (>75 vs ≤75 years) vs Nonblacks, men, and younger patients (≤75 years)
O
Primary Outcome
Incidence of death or MI at 42 days
Cite This Study
Peter Howard Stone (1996) conducted a cohort in Unstable angina or non-Q-wave myocardial infarction (n=3,318). Race (black vs nonblack), sex (women vs men), and age (>75 vs ≤75 years) vs. Nonblacks, men, and younger patients (≤75 years) was evaluated on Incidence of death or MI at 42 days. Blacks (RR 0.65; 95% CI 0.58-0.72) and women (RR 0.71; 95% CI 0.65-0.78) were less likely to undergo invasive procedures than nonblacks and men, yet had similar 42-day rates of death or MI.