Potential of miR-192-5p as a diagnostic marker for children with severe pneumonia and respiratory failure and its predictive value for prognosis

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Introduction: Severe pneumonia in children is a rapidly progressing respiratory system disease. If not promptly controlled, it can lead to respiratory failure, posing a serious threat to the child's life. This study investigated the diagnostic and prognostic potential of miR-192-5p in children with severe pneumonia and respiratory failure. Material and methods: A total of 62 children with severe pneumonia, 40 children with severe pneumonia and respiratory failure, and 62 healthy children were enrolled. The level of miR-192-5p was quantified by RT-qPCR assays. The diagnostic potential of miR-192-5p for severe pneumonia and respiratory failure was assessed through ROC curve and binary logistic analyses. The association between abnormal miR-192-5p level and prognosis of children with severe pneumonia with respiratory failure was evaluated by Kaplan-Meier and multivariate Cox analysis. Results: miR-192-5p expression was decreased in the serum of severe pneumonia and expiratory failure children. miR-192-5p has a good potential to predict the occurrence of severe pneumonia, which is a risk predictor of severe pneumonia in children with respiratory failure. In addition, downregulation of miR-192-5p was strongly associated with poor prognosis of children with severe pneumonia and respiratory failure. Conclusions: A low level of miR-192-5p has high predictive value and clinical development potential for the timely diagnosis and prediction of poor prognosis of children with severe pneumonia and respiratory failure.