Key result
G2A deficiency suppresses atherosclerosis in mice, reducing aortic lesion coverage by ~80%.
Why the study?
The pro-atherogenic role of the G2A receptor in vivo and its effect on atherosclerosis progression and lipoprotein metabolism were not fully understood.
Effect estimate: 62% to 73% reduction at 9 weeks, 75% to 84% reduction at 20 weeks
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G2A loss attenuates aortic atherosclerosis and raises HDL in LDLR-/- mice; leaves open whether targeting G2A could modify human disease risk.
Parks et al. (2006) studied Atherosclerosis. G2A deficiency vs. G2A+/+ (wild-type G2A) was evaluated on Aortic lesion coverage (62% to 73% reduction at 9 weeks, 75% to 84% reduction at 20 weeks). G2A deficiency in LDLR knockout mice robustly suppressed atherosclerosis, reducing aortic lesion coverage by 62% to 73% at 9 weeks and 75% to 84% at 20 weeks of diet intervention.
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