2,4,4-Trirnethyl-3H-5-hydro-l,5-benzodiazepine was obtained by the reaction of o-phenylenediamine and acetonedicarboxylic acid (or acetone) in various methods (Method 1, 2, 3). When o-phenylenediamine was heated with acetophenone in the presence of PPA (or SiO2), 2,4-diphenyl-4-methyl-3H-5-hydro-1,5-benzodiazepine 5 was isolated (Method 4).
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Jung et al. (1999) studied this question.
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