Key result
Oral SODB reduces LV hypertrophy in hypertensive rats while boosting cardiac antioxidant enzymes by ~35%.
Why the study?
The effect of melon superoxide dismutase (SODB) on left ventricular hypertrophy and endogenous antioxidant defense in spontaneously hypertensive rats was assessed.
Answers are grounded in this paper and cite their sources.
We assessed the influence of SODB, a melon superoxide dismutase (SOD), on left ventricular (LV) hypertrophy in SHR. SODB (4 or 40U SOD) was given orally for 4 or 28 days to SHR. For each treatment period, LV weight index (LVWI) and cardiomyocytes size were measured. SOD, glutathione peroxidase (GPx) and catalase expressions, and LV production and presence of superoxide anion were determined. Pro-inflammatory markers were also measured. SODB reduced LVWI and cardiomyocytes size after 4 or 28 days. Cardiac SOD and GPx increased by 30-40% with SODB. The presence but not production of superoxide anion was significantly reduced by SODB. No effect of SODB was detected on inflammatory status in any group. The beneficial effect of SODB on cardiac hypertrophy seems to be related to the stimulation of endogenous antioxidant defense, suggesting that SODB may be of interest as a dietary supplementation during conventional antihypertensive therapy.
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Carillon et al. (2014) studied Hypertension and cardiac hypertrophy. Melon superoxide dismutase (SODB) vs. Untreated/control was evaluated on Left ventricular weight index (LVWI) and cardiomyocyte size. Oral administration of melon superoxide dismutase (SODB) reduced left ventricular weight index and cardiomyocyte size in spontaneously hypertensive rats, while increasing cardiac antioxidant enzymes by 30-40%.
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