Current Clinical Issues21 September 2004Frailty—and Its Dangerous Effects—Might Be PreventableJennifer Fisher WilsonJennifer Fisher WilsonAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-6-200409210-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The differences between a 70-year-old who is robust and one who is frail are easily detectible. Frail older patients are visibly more vulnerable, withdrawn, unsteady, and weak, and they tend to have more complications as they age and a higher rate of hospitalization. In short, doctors know frailty when they see it. But until recently, diagnosing frailty was mostly subjective, and physicians seldom thought of specific treatment. Now medicine has an objective method for diagnosis, and this new method is opening the door for potential treatments. Specialists in the field are moving away from the common view of frailty as ...References1. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al . Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-56. [PMID: 11253156] CrossrefMedlineGoogle Scholar2. Leng S, Chaves P, Koenig K, Walston J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc. 2002;50:1268-71. [PMID: 12133023] CrossrefMedlineGoogle Scholar3. Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, et al . Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162:2333-41. [PMID: 12418947] CrossrefMedlineGoogle Scholar4. Leng SX, Cappola AR, Andersen RE, Blackman MR, Koenig K, Blair M, et al . Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clin Exp Res. 2004;16:153-7. [PMID: 15195991] CrossrefMedlineGoogle Scholar5. Morley JE, Perry HM, Miller DK. Editorial: Something about frailty [Editorial]. J Gerontol A Biol Sci Med Sci. 2002;57:M698-704. [PMID: 12403796] CrossrefMedlineGoogle Scholar6. Lipsitz LA. Physiological complexity, aging, and the path to frailty. Science Aging Knowledge Environment. 2004;16:pe16. 21 April 2004 [DOI: 10.1126/sageke.2004.16.pe16]. Google Scholar7. Walston J. Frailty—the search for underlying causes. Science Aging Knowledge Environment. 2004;4:pe4. 28 January 2004 [DOI: 10.1126/sageke.4.pe4]. Google Scholar8. Studenski S, Perera S, Wallace D, Chandler JM, Duncan PW, Rooney E, et al . Physical performance measures in the clinical setting. J Am Geriatr Soc. 2003;51:314-22. [PMID: 12588574] CrossrefMedlineGoogle Scholar9. Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Van Ness PH. A prehabilitation program for the prevention of functional decline: effect on higher-level physical function. Arch Phys Med Rehabil. 2004;85:1043-9. [PMID: 15241748] CrossrefMedlineGoogle Scholar10. Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. N Engl J Med. 2002;347:1068-74. [PMID: 12362007] CrossrefMedlineGoogle Scholar11. Keysor JJ, Jette AM. Have we oversold the benefit of late-life exercise? J Gerontol A Biol Sci Med Sci. 2001;56:M412-23. [PMID: 11445600] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Disclosures: None disclosed.E-mail:[email protected]org. 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