Key result
Patients receiving beta-adrenergic blocking drugs had a significantly lower correlation between ejection fraction and end-systolic volume index compared with untreated patients.
Why the study?
The relation between ejection fraction and end-systolic volume index and its alteration by chronic beta-adrenergic blockade was not previously described.
Observational
Answers are grounded in this paper and cite their sources.
EF-ESVI relation may aid angiographic assessment; leaves open validation in contemporary cohorts and beta-blocker subgroups.
This study describes the newly discovered relation between ejection fraction and end-systolic volume index (ESVI) of the left ventricle as obtained by angiography at the time of cardiac catheterisation. Linear regression analysis shows that ejection fraction (%)=82.0-0.62 ESVI (ml/m2) but the correlation for patients receiving beta-adrenergic blocking drugs is significantly lower compared with the untreated group. Non-linear analysis, applied to cover also the asymptotic range for ejection fraction less than 20%, shows similar results. The good relation between the two indices indicates that the index ejection fraction may derive its clinical importance directly from the more fundamental index end-systolic volume index by virtue of the operation of the beta-adrenergic system on the heart.
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Kerkhof et al. (1981) conducted an observational in Patients undergoing cardiac catheterisation. Beta-adrenergic blocking drugs vs. Untreated group was evaluated on Correlation between ejection fraction and end-systolic volume index (ESVI). Patients receiving beta-adrenergic blocking drugs had a significantly lower correlation between ejection fraction and end-systolic volume index compared with untreated patients.
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