The Effects of Natural Sleep and Hypersomnolent States on Respiratory Function

Article1 March 1960THE EFFECTS OF NATURAL SLEEP AND HYPERSOMNOLENT STATES ON RESPIRATORY FUNCTIONHERBERT O. SIEKER, M.D., ALBERT HEYMAN, M.D., F.A.C.P., RICHARD I. BIRCHFIELD, M.D.HERBERT O. SIEKER, M.D., ALBERT HEYMAN, M.D., F.A.C.P., RICHARD I. BIRCHFIELD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-500 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe close association between hypersomnolence and alterations in ventilatory function has recently received much attention. Abnormal states of somnolence associated with "central" hypoventilation have been described in a variety of conditions, such as marked obesity,1, 2 barbiturate intoxication,3 myotonic dystrophy4 and encephalitis.5, 6 In a few patients the hypoventilation phenomenon associated with somnolence has been attributed to a localized lesion in the medullary portion of the central nervous system, even though there was little evidence of neurologic illness by history or physical examination.7, 8It appeared likely that a better understanding of this problem could be obtained by a study...Bibliography1. BurwellRobinWhaleyBickelmann CSEDRDAG: Extreme obesity associated with alveolar hypoventilation—a Pickwickian syndrome, Am. J. Med. 21: 811, 1956. CrossrefMedlineGoogle Scholar2. EstesSiekerMcIntoshKelser EHHOHDGA: Reversible cardiopulmonary syndrome with extreme obesity, Circulation 16: 179, 1957. CrossrefMedlineGoogle Scholar3. WilsonHosethDempsey RHWME: Respiratory acidosis. I. 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DeBruin M: Respiration and basal metabolism in childhood during sleep, Acta paediat. 279: 18, 1936. Google Scholar10. Magoun HW: The waking brain, 1958, Charles C Thomas, Springfield, Illinois. CrossrefGoogle Scholar11. KaadaJasper BRH: Respiratory responses to stimulation of temporal pole, insula and hippocampal and limbic gyri in man, Arch. Neurol. and Psychiat. 68: 609, 1952. CrossrefGoogle Scholar12. Endres G: Atmungsregulation und Blutreaktion im Schlaf, Biochem. Ztschr. 142: 53, 1923. Google Scholar13. MangoldSokoloffConnerKleinermanThermanKety RLEJPGS: The effects of sleep and lack of sleep on the cerebral circulation and the metabolism of normal young men, J. Clin. Investigation 34: 1092, 1955. CrossrefMedlineGoogle Scholar14. BirchfieldSiekerHeyman RIHOA: Alterations in blood gases during natural sleep and narcolepsy, Neurology 8: 107, 1958. CrossrefMedlineGoogle Scholar15. BirchfieldSiekerHeyman RIHOA: Alterations in respiratory function during natural sleep, J. Lab. and Clin. Med. 54: 216, 1959. MedlineGoogle Scholar16. RobinWhaleyCrumpTravis EDRDCHDM: Alveolar gas tensions, pulmonary ventilation and blood pH during physiologic sleep in normal subjects, J. Clin. Investigation 37: 981, 1958. CrossrefMedlineGoogle Scholar17. Wilson SA: The narcolepsies, Brain 51: 63, 1928. CrossrefGoogle Scholar18. Daniels LE: Narcolepsy, Medicine 13: 1, 1934. CrossrefGoogle Scholar19. MartinSieker AHO: Unpublished data. Google Scholar20. HeymanBirchfieldSieker ARIHO: Effects of bilateral cerebral infarction on respiratory center sensitivity, Neurology 8: 694, 1958. CrossrefMedlineGoogle Scholar21. Gallinek A: The syndrome of episodes of hypersomnia, bulimia and abnormal mental states, J. A. M. A. 154: 1081, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina*Received for publication November 13, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 22, 1959.From the Department of Medicine (Neurology and Pulmonary Divisions), Duke University Medical Center, and the Veterans Administration Hospital, Durham, North Carolina.†Supported by Research Grant B669, National Institutes of Health, U. S. Public Health Service, and by a grant from the American Heart Association.‡Present address: Division of Neurology, University of Washington School of Medicine, Seattle.Requests for reprints should be addressed to Herbert O. Sieker, M.D., Department of Medicine, Duke Hospital, Durham, North Carolina. 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