Regional versus general anesthesia in high-risk surgical patients: The need for a clinical trial
Key result
Regional anesthesia is linked to more perioperative myocardial ischemia or infarction than general anesthesia.
- P<0.015
- n=134
Why the study?
Few studies have directly addressed whether the type of anesthesia is independently associated with perioperative myocardial ischemia in patients with cardiovascular disease.
Population
134 patients undergoing peripheral vascular grafting
Comparison
Regional anesthesia vs general anesthesia
Design
Observational study
Follow-up
7 days
Authors
Discussion
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Implication
Anesthesia type was not associated with perioperative myocardial ischemia; leaves open whether regional anesthesia reduces cardiac risk in vascular surgery.
Study Design
Type
Observational (n=134)
PICO
P
Population
134 patients undergoing peripheral vascular grafting under general or regional anesthesia, evaluated for perioperative myocardial ischemia or infarction within 7 days.
E
Exposure / Comparator
Regional anesthesia vs General anesthesia
O
Primary Outcome
Myocardial ischemia or infarction within 7 days of operation, p=<0.015
Main Result
p-value: p=<0.015
Cite This Study
Manolio et al. (1989) conducted an observational in Peripheral vascular grafting (n=134). Regional anesthesia vs. General anesthesia was evaluated on Myocardial ischemia or infarction within 7 days of operation (p=<0.015). Regional anesthesia was associated with a higher number of perioperative myocardial ischemia or infarction events compared to general anesthesia (11 vs 1 events; p<0.015).