Key result
OLR1 IVS4-14 A>G genotype distribution did not differ between Metabolic Syndrome and controls (GG: 22% vs 18%, p=NS), though GG was associated with higher type 2 diabetes frequency (60% vs 16%, p=0.005).
Why the study?
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, has been implicated in the pathogenesis of atherosclerosis, motivating evaluation of OLR1 genotyping in patients with Metabolic Syndrome, a condition characterized by high cardiovascular risk.
Is the OLR1 IVS4-14 A>G polymorphism associated with Metabolic Syndrome, its metabolic components, and oxidative stress markers in adults?
Case-Control (n=94)
No
Is the OLR1 IVS4-14 A>G polymorphism associated with Metabolic Syndrome, its metabolic components, and oxidative stress markers in adults?
Answers are grounded in this paper and cite their sources.
Although the OLR1 IVS4-14 A>G polymorphism frequency does not differ between Metabolic Syndrome patients and controls, the GG genotype is associated with impaired glucose metabolism, insulin resistance, microalbuminuria, and increased carotid intima-media thickness.
AIMS: The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, has been implicated in the pathogenesis of atherosclerosis. We therefore evaluated the genotyping of OLR1 gene in a sample of 55 patients with Metabolic Syndrome, a clinical condition characterized by a high cardiovascular risk. METHODS AND PATIENTS: The genotyping of the LOX-1 was performed by polymerase chain reaction (PCR) analysis of the IVS4-14 A>G OLR1 polymorphism embedded within the OLR1 Linkage Disequilibrium block. Patients were assessed for routine serum parameters, microalbuminuria, insulin resistance (HOMA) and oxidative stress (thiobarbituric acid reactive substances, TBARs and thioredoxin). RESULTS: The allele or genotype distribution of the OLR1 IVS4-14 A>G was not statistically different between MS and controls subjects. A positive association was found between IVS4-14 GG genotype, microalbuminuria and fasting glycaemia as well as a higher frequency of type 2 diabetes, elevated microalbuminuria, fasting serum glucose and HOMA index in the same subjects. Thioredoxin values were higher in patients with MS but did not differ in relation to OLR1 IVS4-14 A>G genotype. The TBARs/Cholesterol ratio was higher in MS both in IVS4-14 GG and in IVS4-14 AG. CONCLUSION: IVS4-14 GG genotype seems to be related to glucose metabolism disturbance, elevated insulin level and lipid peroxidation in patients with MS.
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Palmieri et al. (2012) conducted a case-control in Metabolic Syndrome (n=94). OLR1 IVS4-14 A>G polymorphism (GG risk genotype) vs. Healthy controls without Metabolic Syndrome / AA and AG genotypes was evaluated on Distribution of OLR1 IVS4-14 GG risk genotype between Metabolic Syndrome patients and controls (p=NS). OLR1 IVS4-14 A>G genotype distribution did not differ between Metabolic Syndrome and controls (GG: 22% vs 18%, p=NS), though GG was associated with higher type 2 diabetes frequency (60% vs 16%, p=0.005).
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