Key result
Bilateral radial artery grafting is linked to ~26% lower long-term mortality vs no radial use.
Why the study?
The survival benefit associated with bilateral radial artery use in coronary artery bypass grafting was not well established.
Does bilateral radial artery grafting improve long-term survival in patients undergoing primary isolated CABG compared to single or no radial artery grafting?
Cohort (n=59,608)
Yes
Does bilateral radial artery grafting improve long-term survival in patients undergoing primary isolated CABG compared to single or no radial artery grafting?
Hazard Ratio: 0.74 (95% CI 0.67–0.82)
p-value: p=<.001
May support multiarterial grafting in CABG; extends observational data but leaves randomized confirmation open.
Objectives: Radial artery (RA) is recommended as a graft for the second most important coronary target after the left internal thoracic artery-to-left anterior descending artery graft. This study assessed the survival benefit associated with bilateral RA use in coronary artery bypass grafting (CABG). Methods: This was a retrospective analysis of prospectively collected data from a binational database including patients who underwent CABG with ≥2 grafts from 2001 to 2020. Patients were stratified into 3 groups: no RA (RA-0), single RA (RA-1), and bilateral RA (RA-2) use. Inverse probability of treatment weighting was used to adjust for baseline differences. The outcome analyzed was long-term all-cause mortality. Results: = .10). Total arterial revascularization was achieved in 7.1%, 46.2%, and 81.0% of RA-0, RA-1, and RA-2 groups, respectively. Conclusions: Bilateral RA grafting was associated with superior long-term survival compared with the use of 1 RA or no RA conduit. Increased adoption of RA conduits in CABG is encouraged, and preservation of both RAs is recommended when CABG is anticipated.
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Hamilton et al. (2026) conducted a cohort in Severe multivessel coronary artery disease requiring CABG (n=59,608). Bilateral radial artery grafting vs. No radial artery grafting (RA-0) was evaluated on Long-term all-cause mortality (HR 0.74, 95% CI 0.67-0.82, p=<.001). Bilateral radial artery grafting was associated with a significant reduction in long-term all-cause mortality compared with no radial artery use (HR 0.74).
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