Key result
Multimodal non-drug physiotherapy cuts HOMA-IR by ~51% in menopausal metabolic syndrome.
Why the study?
The potential of non-drug correction strategies to reduce cardiovascular risk in women with metabolic syndrome during menopause was not well studied.
RCT (n=330)
Open-label
Randomized
No
Absolute Event Rate: 2.68% vs 4.74%
p-value: p=<0.0001
May support multimodal physiotherapy in menopausal metabolic syndrome; hypothesis-generating and requires randomized confirmation before practice change.
Objective: To study the possibilities of non-drug correction of metabolic and endocrine disorders in women with metabolic syndrome (MS) in menopause.Design: Participants are divided into 5 groups depending on the programs used, each of the groups is divided into 2 subgroups -menopausal syndrome (MPS) of mild to moderate degree.Setting: Estimated levels of follicle-stimulating (FSH), luteinizing (LH) hormones, estradiol, hemostasis, glycemic status, lipid profiles, Green test.Participants: 330 women aged 45-50 with menopausal syndrome (MPS) and MS.Interventions: Standard approach, physical therapy, balneotherapy, multivitamins and minerals, physiotherapy (vibrotherapy, chromotherapy, melotherapy, aromatherapy, aeroionotherapy) in various combinations. Main outcome measures: Mann-Whitney test, criterion Kruskal-Wallis, Wilcoxon criterion.Results: In patients with mild MPS, when using programs with physiotherapy, HOMA-IR decreased by 50%, the atherogenic index by more than 25%, the INR level increased by more than 4,0%, the total Green score decreased by more than 40,0%.in patients with moderate MPS, the treatment complex with the simultaneous use of vibrotherapy, chromotherapy, melootherapy, aromatherapy and aeroionotherapy had the advantage: HOMA-IR decreased by 50,5%, atherogenic index by 30,5%, INR increased by 5,0%, overall score on the Green scale decreased by 40,0%.Conclusion: In patients with MPS and MS, non-drug programs using physical therapy have a positive effect on the functioning of the endocrine system, hemostasis, carbohydrate and fat metabolism which helps reduce the risk of cardiovascular events.In case of moderate MPS against the background of MS, the program with simultaneous use of vibrotherapy, chromotherapy, melotherapy, aromatherapy and aeroionotherapy has an advantage.
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Бериханова et al. (2020) conducted an RCT in Menopausal syndrome and metabolic syndrome (n=330). Multimodal non-drug program (physiotherapy, balneotherapy, vitamins, exercise, diet) vs. Basic treatment (diet, exercise, lifestyle modification) was evaluated on HOMA-IR at 6 months (p=<0.0001). In women with moderate menopausal syndrome and metabolic syndrome, a comprehensive non-drug program including multimodal physiotherapy reduced HOMA-IR by 50.5% and the atherogenic index by 30.5% at 6 months.
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