Key result
Lower HDL-C correlates with higher CAD risk, though genetic deficiency shows variable cardiovascular outcomes.
Why the study?
The complex roles and genetic variations of high-density lipoprotein cholesterol in coronary artery disease and longevity require comprehensive understanding for therapeutic modulation.
Design
Review
Authors
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HDL pleiotropic effects on thrombosis and adhesion remain hypothesis-generating; leaves open whether they alter CAD outcomes.
Jacques J. Genest (2002) conducted a review in Coronary artery disease. High-density lipoprotein cholesterol was evaluated. High-density lipoprotein cholesterol levels are inversely correlated with coronary artery disease, with genetic mutations causing HDL deficiency linked to premature CAD or paradoxically to longevity.
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