Key result
High blood pressure in metabolic syndrome is linked to adverse metabolic, inflammatory, and prothrombotic dysregulation.
Why the study?
The association of high blood pressure with metabolic, inflammatory, and prothrombotic dysregulation in patients with metabolic syndrome was explored.
Cross-Sectional (n=75)
No
May flag higher-risk metabolic syndrome subsets; leaves open whether biomarkers predict events or respond to BP control.
OBJECTIVES: We explored whether high blood pressure is associated with metabolic, inflammatory and prothrombotic dysregulation in patients with metabolic syndrome. METHODS: We evaluated 135 consecutive overweight/obese patients. From this group, we selected 75 patients who were not under the regular use of medications for metabolic syndrome as defined by the current Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults criteria. The patients were divided into metabolic syndrome with and without high blood pressure criteria (≥130/≥85 mmHg). RESULTS: Compared to the 45 metabolic syndrome patients without high blood pressure, the 30 patients with metabolic syndrome and high blood pressure had significantly higher glucose, insulin, homeostasis model assessment insulin resistance index, total cholesterol, low-density lipoprotein-cholesterol, triglycerides, uric acid and creatinine values; in contrast, these patients had significantly lower high-density lipoprotein-cholesterol values. Metabolic syndrome patients with high blood pressure also had significantly higher levels of retinol-binding protein 4, plasminogen activator inhibitor 1, interleukin 6 and monocyte chemoattractant protein 1 and lower levels of adiponectin. Moreover, patients with metabolic syndrome and high blood pressure had increased surrogate markers of sympathetic activity and decreased baroreflex sensitivity. Logistic regression analysis showed that high-density lipoprotein, retinol-binding protein 4 and plasminogen activator inhibitor-1 levels were independently associated with metabolic syndrome patients with high blood pressure. There is a strong trend for an independent association between metabolic syndrome patients with high blood pressure and glucose levels. CONCLUSIONS: High blood pressure, which may be related to the autonomic dysfunction, is associated with metabolic, inflammatory and prothrombotic dysregulation in patients with metabolic syndrome.
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Gil et al. (2013) conducted a cross-sectional in Metabolic syndrome (n=75). High blood pressure (≥130/≥85 mmHg) vs. Metabolic syndrome without high blood pressure (<130/<85 mmHg) was evaluated on Independent association of metabolic, pro-inflammatory, and prothrombotic markers with high blood pressure in metabolic syndrome. In patients with metabolic syndrome, the presence of high blood pressure is independently associated with metabolic, inflammatory, and prothrombotic dysregulation, including altered levels of HDL, RBP4, and PAI-1.
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