Key result
Adding alinidine to dobutamine lowers heart rate and increases stroke volume index.
Why the study?
The cardiovascular effects of dobutamine and the impact of selective inhibition of chronotropic effects by N-allyl-clonidine on cardiac function were not fully understood.
Answers are grounded in this paper and cite their sources.
Dobutamine may not augment LVSV in surgical patients despite CI gains; leaves open alinidine's adjunctive role.
The cardiovascular effects of dobutamine ( 7 micrograms/kg . min iv) and of additional N-allyl-clonidine (St 567, alinidine; 0.3 mg/kg iv), a compound which selectively inhibits the chronotropic effects of various stimulants, were studied in 9 patients scheduled for major abdominal surgery. Dobutamine increased cardiac index (CI), mean arterial pressure (MAP), mean pulmonary artery pressure (MPAP), and heart rate, but failed to change the left ventricular stroke volume (LVSV) significantly. Alinidine decreased cardiac rate and increased LVSV index and left ventricular stroke work index (LVSWI), whereas CI, MAP, and MPAP remained virtually unaffected. Similar results were obtained when the combination of dobutamine and alinidine was given to 4 patients in neuroleptanesthesia. Thus, the decrease in preload which is associated wit tachycardia seems to modify the increase in LVSV in response to inotropic stimulation with dobutamine.
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ZIMPFER et al. (1982) studied Scheduled for major abdominal surgery (n=13). Dobutamine and N-allyl-clonidine (alinidine) was evaluated on Cardiovascular effects including cardiac index, mean arterial pressure, mean pulmonary artery pressure, heart rate, and left ventricular stroke volume. Dobutamine increased cardiac index, mean arterial pressure, and heart rate, while the addition of alinidine decreased heart rate and increased left ventricular stroke volume index.
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