Primary Cutaneous Plasmablastic Lymphoma as First Sign of Human Immunodeficiency Virus Infection

This is the authors' abstract. We don't add key points for this paper.

Plasmablastic lymphoma (PBL) is an uncommon lymphoid neoplasm characterized by a diffuse proliferation of large neoplastic cells similar to B immunoblasts but with immunophenotypic features resembling plasma cells, originally reported in the oral cavity in human immunodeficiency virus–infected patients. This lymphoma may be observed also in the setting of other types of immune suppression and even in non–immune-suppressed individuals. We report on a 48-year-old man who presented with a large, exophytic tumor of 3-month duration located to the sacral region, classified as PBL upon histopathologic and phenotypic features. The lymphoma represented the first sign of a yet undiagnosed infection by human immunodeficiency virus. This review addresses the clinical, histopathologic, phenotypic, differential diagnostic, and prognostic features of cutaneous PBL.