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September 25, 2026Bioorganic & Medicinal ChemistryOpen Access

Criteria-guided selection of alternative zinc-binding groups of HDAC3 inhibitors using in silico and in vitro approaches

Thabo Brighton Makgoba Samuel Egieyeh Erika Kapp Jacques Joubert

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Abstract

on liver (HepG2) cells was >100 μM, while HDAC3 inhibition occurred at sub-micromolar concentrations. Compound b showed HDAC3 inhibitory preference without inducing cytotoxicity on liver and neuroblastoma cells.

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Makgoba et al. (2026) studied this question.

synapsesocial.com/papers/6ac49538d60aa66ad775c578 https://doi.org/10.1016/j.bmc.2026.118810

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