Key result
Higher thyroid radiation dose linked to ~143% higher early hypothyroidism risk in breast radiotherapy.
Why the study?
The concept of relative radioresistance of normal thyroid tissue after high-dose bilateral neck irradiation in lymphoma patients requires revision due to observed thyroid dysfunction.
Population
174 lymphoma patients receiving high-dose bilateral neck irradiation
Comparison
Patients with and without neck irradiation and lymphangiography
Design
Cohort study
Follow-up
At least quarterly post-treatment evaluation
Authors
Loading...
May warrant thyroid monitoring after breast radiotherapy; hypothesis-generating and challenges assumptions of normal thyroid radioresistance.
Observational (n=109)
No
Odds Ratio: 2.432 (95% CI 1.015–5.826)
p-value: p=0.046
GLATSTEIN et al. (1971) conducted an observational in Non-metastatic breast cancer (n=109). Thyroid radiation exposure (V40) vs. Lower thyroid radiation exposure was evaluated on Development of hypothyroidism at 6 months (OR 2.432, 95% CI 1.015-5.826, p=0.046). In women receiving loco-regional breast radiotherapy, higher radiation doses to the thyroid gland (V40) significantly increased the risk of early hypothyroidism at 6 months (OR 2.432).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: