Key result
Exercise-induced septal systolic dysfunction identifies patients with LMCA or proximal LAD stenosis.
Why the study?
Detection of stenosis in the left main or proximal left anterior descending coronary artery by echocardiographic evaluation during exercise was investigated to improve diagnostic methods.
Observational (n=40)
Exercise septal hypokinesia may flag proximal stenosis; hypothesis-generating and requires prospective validation before any clinical use.
Forty patients with coronary artery disease were studied prospectively to investigate whether stenosis of the left main (LMCA) or left anterior descending coronary artery, proximal to the first septal branch (proximal LAD), could be detected by M-mode echocardiography during exertion. The interventricular septum was visualized in 30 of the patients during bicycle exercise in the semisupine position, all with simultaneous occurrence of electrocardiographic evidence of myocardial ischaemia. Fifteen of these had LMCA or proximal LAD stenosis. Systolic motion and thickening of the septum decreased significantly from rest to peak exercise in patients with LMCA or proximal LAD disease while it increased in those without. The results suggest that M-mode echocardiography during exercise in patients with coronary artery disease might identify those with LMCA or proximal LAD stenosis.
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Vik‐Mo et al. (1986) conducted an observational in Coronary artery disease (n=40). M-mode echocardiography during exertion vs. Resting state / Patients without LMCA or proximal LAD stenosis was evaluated on Systolic motion and thickening of the interventricular septum from rest to peak exercise. M-mode echocardiography during exercise revealed that systolic motion and thickening of the septum decreased significantly in patients with LMCA or proximal LAD stenosis, while increasing in those without.
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