Key result
CAD progresses in ~32% of patients over three years, even among those with stabilized symptoms.
Why the study?
The progression or regression of coronary artery disease over time in patients with significant coronary artery narrowing was not well characterized.
Population
227 patients with ≥50% narrowing in at least one major coronary artery
Comparison
Coronary artery lesion changes between initial and follow-up arteriography
Design
Cohort study with restudy of coronary arteriography
Follow-up
Mean interval of 35.6 months
Authors
Loading...
Coronary lesion progression in one-third of patients over 3 years, even when stable, warrants caution; leaves open optimal surveillance intervals today.
Cohort (n=227)
Ishikawa et al. (1986) conducted a cohort in Coronary artery disease (n=227). Time (natural history of coronary artery disease) was evaluated on Progression of coronary arterial lesions (change of ≥2 stages). Over a mean interval of 35.6 months, progression of coronary artery disease occurred in 32% of patients, including 22% of those with stabilized symptoms.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: