Key result
Aortic valve replacement linked to ~77% lower mortality vs medical therapy in endocarditis with severe HF.
Why the study?
High mortality rates in patients with bacterial endocarditis, aortic valve insufficiency, and heart failure treated medically motivated evaluation of valve replacement outcomes.
Early valve replacement may lower mortality in severe heart-failure cases; leaves open optimal timing thresholds for milder aortic insufficiency.
Comments and Corrections1 November 1973Bacterial Endocarditis: Valve Replacement in Aortic InsufficiencyJAMES S. BORGES, M.D., RICHARD B. ROBERTS, M.D., F.A.C.P., WARREN D. JOHNSON, M.D., F.A.C.P.JAMES S. BORGES, M.D.Search for more papers by this author, RICHARD B. ROBERTS, M.D., F.A.C.P.Search for more papers by this author, WARREN D. JOHNSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-757 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGriffin, Jones, and Cobbs (Ann Intern Med76:23-28, 1972) report a 74% mortality rate in patients with bacterial endocarditis, aortic valve insufficiency, and heart failure who received only medical therapy (1). The patients were divided into three groups: Group 1, no heart failure; group 2, mild heart failure (controlled by digitalis alone); and group 3, moderate to severe heart failure (requiring digitalisanddiuretic therapy). Seven of eight patients withmoderateorsevereheart failure treated medically died, whereas only one of five withsevereheart failure who had aortic valve replacement died. Their conclusion that patients with severe heart...References1. WILSONWILCOXSUGG LBW: Valvar regurgitation in acute infective endocarditis: early replacement. Arch Surg 101:756-759, 1970 CrossrefMedlineGoogle Scholar2. MANHASMOHRIHESSEL DHE: Experience with surgical management of primary infective endocarditis: a collected review of 139 patients. Am Heart J 84:738-747, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Infectious Diseases Department of Medicine Cornell University Medical College New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatment 1 November 1973Volume 79, Issue 5Page: 757-757KeywordsAortic valveAortic valve replacementDeath ratesDiureticsEndocarditisHeartHeart failureValve replacement Issue Published: 1 November 1973 PDF downloadLoading ...
No takes yet. Share an insight, caveat, or question.
James S. Borges (1973) conducted a letter in Bacterial endocarditis, aortic valve insufficiency, and heart failure (n=13). Aortic valve replacement vs. Medical therapy was evaluated on Mortality. Aortic valve replacement resulted in 20% mortality (1 of 5 patients) compared to 87.5% (7 of 8 patients) with medical therapy in patients with bacterial endocarditis and severe heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: