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September 1, 1942Annals of Internal Medicine

Bacterial Endocarditis and Congenital Heart Disease (With Report of Two Cases)

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Population

2 cases of congenital heart disease terminating fatally with bacterial endocarditis

Design

Case_series

Authors

AAA. AntenucciNational Cancer InstituteGEGail EckhardtDELL (United States)

Discussion

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Overview

Highlights potential for rapid fatal decline in congenital heart disease with endocarditis; hypothesis-generating for prevention strategies today.

Key Points

  • Describe fatal presentations and severe complications of bacterial endocarditis occurring in patients with congenital heart defects.
  • Clinical and pathological evaluation of two fatal cases presenting with bacterial endocarditis superimposed on underlying congenital cardiac anomalies.
  • Bacterial endocarditis superimposed on a bicuspid aortic valve resulted in rapid, severe tissue destruction and fatal clinical decline.
  • Infection localized to the margins of a ventricular septal defect induced complete auriculo-ventricular dissociation secondary to localized conduction system disruption.

Structured PICO

P
Population
2 cases of congenital heart disease terminating fatally with bacterial endocarditis (Case 1: 36-year-old white man with bicuspid aortic valve; Case 2: ventricular septal defect with acquired complete auriculo-ventricular dissociation)
O
Outcome
Fatal termination (death)hard clinical

The report illustrates the devastating and fatal effects of bacterial endocarditis superimposed on congenital heart lesions such as bicuspid aortic valve and ventricular septal defect.

Cite This Study

Antenucci et al. (1942) studied this question.

synapsesocial.com/papers/6a88f0fbcd9902a7ca1266aehttps://doi.org/10.7326/0003-4819-17-3-511
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Also Consider

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  5. 5ACQUIRED HEART BLOCK WITH ADAMS-STOKES ATTACKS DEPENDENT UPON A CONGENITAL ANOMALY (PERSISTENT OSTIUM PRIMUM)1934 · 21 citations