In most cases, patients presenting with "the worst headache ever" are found to have a benign condition, notably migraine, toxic vascular headache, or exertion-induced headache. However, ominous causes first must be excluded by appropriate investigation, such as computed tomographic or magnetic resonance imaging scans and lumbar puncture. When an ominous cause has been ruled out, appropriate therapy can be started.
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John G. Edmeads (1989) studied this question.
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