Key result
Elevated troponin linked to ~3-fold higher hospital mortality in critically ill non-ACS patients.
Why the study?
The prognostic value of initial elevation in cardiac troponin I level within 24 hours in critically ill patients without acute coronary syndrome was uncertain.
Cohort (n=90)
Elevated troponin may identify higher-risk non-ACS ICU patients; leaves open whether monitoring should guide interventions.
BACKGROUND: Cardiac troponin I levels are often obtained to help rule out acute coronary syndrome. OBJECTIVE: To determine if elevation of troponin level within 24 hours for patients without acute coronary syndrome admitted to the intensive care unit provides important prognostic information. METHODS: Patients without acute coronary syndrome admitted to the intensive care unit were prospectively divided into 2 groups according to highest serum level of cardiac troponin I within 24 hours of admission (elevated > 0.049 ng/mL; control ≤ 0.049 ng/mL). Hospital mortality, incidence of intubation, and other parameters were compared between the 2 groups. RESULTS: Patients with elevated troponin level (n = 40) had higher mortality than did control patients (n = 50) (35% vs 12%; P= .01). Compared with control patients, patients with elevated levels were more likely to be intubated (41% vs 17%; P= .02). CONCLUSION: Critically ill patients without acute coronary syndrome with elevated levels of cardiac troponin I at admission had higher mortality and more intubations than did control patients.
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Liu et al. (2015) conducted a cohort in Critically ill without acute coronary syndrome (n=90). Elevated cardiac troponin I level (> 0.049 ng/mL) vs. Cardiac troponin I level ≤ 0.049 ng/mL was evaluated on Hospital mortality (p=.01). Elevated cardiac troponin I levels (>0.049 ng/mL) in critically ill patients without acute coronary syndrome were associated with higher hospital mortality compared to controls (35% vs 12%; P=.01).
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