What is the clinical evidence from this study?

Population: Arterial fibre structure (n=1). Intervention: Diffusion Tensor Imaging (DTI). Primary outcome: Fibre angle orientation.

What does this research mean for the field?

Diffusion tensor imaging and fibre tractography can resolve the helical fibrous structure and alignment of aortic tissue, demonstrating feasibility for noninvasive assessment of arterial structural properties. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 3, 2010EURASIP Journal on Advances in Signal ProcessingOpen Access

Imaging Arterial Fibres Using Diffusion Tensor Imaging—Feasibility Study and Preliminary Results

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Key result

Diffusion tensor imaging feasibility confirmed for resolving helical arterial fiber architecture in porcine aorta.

Why the study?

Noninvasive diagnostic tools to assess the structural properties and changes in arterial tissue are currently being developed, and the feasibility of diffusion tensor imaging for this purpose was investigated.

Population

Fresh porcine aorta tissue

Design

Feasibility study using 7T MR diffusion tensor imaging

Authors

VFVittoria FlaminiNew York University CKChristian KerskensTrinity College KMKevin M. MoermanOllscoil na Gaillimhe – University of Galway

Discussion

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Implication

DTI feasible for arterial fibre mapping in porcine models; extends preclinical imaging research but leaves human translation open.

PICO

Population

One fresh thoracic-abdominal aorta harvested from a six-month-old pig, imaged ex vivo to assess the feasibility of DTI for determining arterial fibre structure.

Intervention / Comparator

Diffusion Tensor Imaging (DTI)

Primary Outcome

Fibre angle orientation

Limitations

Lack of direct validation through histology or other microscopic techniques
Analysis of a vessel in the unloaded configuration, whereby the longitudinal stretch was lost

Cite This Study

Flamini et al. (2010) studied Arterial fibre structure (n=1). Diffusion Tensor Imaging (DTI) was evaluated on Fibre angle orientation. Diffusion tensor imaging and fibre tractography of a porcine aorta successfully identified two dominant helical fibre angles of 15±2.5° and 175±2.5°, demonstrating the feasibility of DTI for assessing arterial structure.

synapsesocial.com/papers/6ac49ec4403b0aaecbbcb72b https://doi.org/10.1155/2010/904091

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Imaging Arterial Fibres Using Diffusion Tensor Imaging—Feasibility Study and Preliminary Results

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Imaging Arterial Fibres Using Diffusion Tensor Imaging—Feasibility Study and Preliminary Results

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

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