Key result
ICIs induce cardiovascular toxicities, including myocarditis and atherosclerosis, driven by T-cell-mediated injury.
Why the study?
The tissue specificity of cardiac troponin I, cardiac troponin T, and CK-MB for detecting myocardial injury required clarification to resolve diagnostic uncertainties.
Comparison
Cardiac troponin I and T vs CK-MB specificity for cardiac damage
Design
Review of human and animal studies
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Alerts clinicians to monitor for ICI-related myocarditis; leaves open optimal troponin-based detection strategies.
A 1999 study conducted a review in Immune checkpoint inhibitor-associated cardiotoxicity. Immune checkpoint inhibitors was evaluated. Immune checkpoint inhibitors induce a spectrum of cardiovascular immune-related adverse events, including myocarditis and atherosclerosis, driven by dysregulated immune activation and T-cell-mediated myocardial injury.
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