Key result
Estrogen deficiency fails to significantly increase cartilage degeneration in postmenopausal women.
Why the study?
Coronary circulation anomalies are an uncommon cause of chest pain when hemodynamically significant, and superdominant RCA with absent LCx is a rare anomaly that can mimic atherosclerotic disease clinically.
Meta-Analysis
Standardized Mean Difference: -0.41 (95% CI -1.02–0.2)
p-value: p=0.19
Estrogen deficiency signals cartilage risk in models but not women; leaves open postmenopausal OA prevention trials.
Coronary circulation anomalies are the uncommon cause of chest pain when hemodynamically significant. Multidetector computed tomography (CT) of coronary arteries is rapidly replacing conventional angiography, nowadays, as the first line of investigation for the imaging of coronary artery disease due to its noninvasive nature. CT coronary angiography in addition to diagnosing anomalies of coronary arteries is especially good in the delineation of ostial origin and proximal course. Superdominant right coronary artery (RCA) with absent left circumflex artery (LCx) is such a rare congenital coronary artery anomaly which can mimic atherosclerotic disease clinically with very few case reports in the literature which can be diagnosed and evaluated with accuracy by CT angiography.
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Nathani et al. (2019) conducted a meta-analysis in Osteoarthritis and cartilage degeneration. Estrogen deficiency / Menopause vs. Premenopausal women or non-OVX controls was evaluated on Cartilage degeneration (human pooled results) (SMD -0.41, 95% CI -1.02 to 0.20, p=0.19). Estrogen deficiency significantly contributed to cartilage degeneration in ovariectomized animal models (SMD -1.72), whereas pooled results in postmenopausal women showed a non-significant trend toward greater degeneration (SMD -0.41).
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