Key result
PE diagnosis delay over 1 day is linked to ~19% lower 1-year major events.
Why the study?
Delay in diagnosis of pulmonary embolism in emergency departments remains a significant clinical problem that needs to be characterized and addressed.
Cohort (n=1,878)
No
Hazard Ratio: 0.812 (95% CI 0.677–0.974)
Absolute Event Rate: 23% vs 28.7%
p-value: p=0.025
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Diagnostic delay in pulmonary embolism should not alter urgency; hypothesis-generating for severity bias and requires prospective validation.
Aydoğdu et al. (2012) conducted a cohort in Acute symptomatic pulmonary embolism (n=1,878). Onset-to-diagnosis > 1 day vs. Onset-to-diagnosis ≤ 1 day was evaluated on 1-year composite outcomes (death, VTE recurrence, and major bleeding) (HR 0.812, 95% CI 0.677-0.974, p=0.025). An onset-to-diagnosis time of more than 1 day was independently associated with a lower risk of 1-year composite outcomes (HR 0.812) compared to 1 day or less, reflecting that more severe pulmonary embolism cases present and are diagnosed more rapidly.
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