Key result
Adrenal medullary transplantation shows limited efficacy in progressive supranuclear palsy, helping only 1 of 3 patients.
Why the study?
The efficacy of autologous adrenal medullary transplantation in progressive supranuclear palsy was uncertain.
Case Report (n=3)
We transplanted autologous adrenal medullary cells to the caudate nucleus in 3 patients with progressive supranuclear palsy, using the method Madrazo has employed for neural transplantation in Parkinson's disease. Major and minor complications occurred post-operatively from which the patients recovered. One patient had a marked improvement in his postural stability and a decreased incidence of falling. This change was evident at 1 month after surgery and has remained for the 6 months of follow-up. Postural reflexes were not altered in the other 2 patients. There was no change in extraocular movements, speech, or the rigid-bradykinetic features of parkinsonism in any patient. Adrenal medullary transplantation has only limited efficacy in progressive supranuclear palsy.
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Koller et al. (1989) conducted a case report in progressive supranuclear palsy (n=3). Autologous adrenal medullary transplant was evaluated on Clinical improvement (postural stability, extraocular movements, speech, rigid-bradykinetic features). Autologous adrenal medullary transplantation showed limited efficacy in progressive supranuclear palsy, with only 1 of 3 patients experiencing improved postural stability at 6 months.
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