Key result
Intravenous labetalol plus oral doxazosin successfully controls pediatric catecholamine-induced hypertensive crisis.
Why the study?
Severe hypertensive crisis due to catecholamine excess in children with neuroblastoma is rare and optimal prolonged treatment strategies are not well defined.
Case Report (n=1)
No
Should not yet change practice in pediatric catecholamine crisis; leaves open need for prospective evaluation.
We describe a case of a 2-year-old boy with neuroblastoma and high catecholamine levels which developed a severe hypertensive crisis. An oral propranolol and oral angiotensin-converting enzyme inhibitor were used with a mild short transient benefit. However, an intravenous labetalol and oral doxazosin used for over 3 weeks resulted in successful blood pressure control. This report highlights the prolonged use of α and β-adrenergic antagonist therapy in children with neuroblastoma with refractory catecholamine-induced hypertension.
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Raciborska et al. (2015) conducted a case report in Neuroblastoma with severe hypertensive crisis (n=1). Intravenous labetalol and oral doxazosin was evaluated on Blood pressure control. Prolonged administration of intravenous labetalol and oral doxazosin resulted in successful blood pressure control in a 2-year-old boy with a catecholamine-induced hypertensive crisis.
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