Key result
Chemotherapy and tumor resection normalize BP and reverse cardiomyopathy in two neuroblastoma cases.
Case Report (n=2)
Treatment of neuroblastoma with chemotherapy and tumor resection can reverse associated severe cardiomyopathic changes and hypertension.
May warrant cardiac screening in hypertensive neuroblastoma; leaves open optimal management and anthracycline decisions.
Catecholamine-associated cardiomyopathies caused by neuroblastoma have rarely been reported. We are reporting 2 cases of neuroblastoma associated with hypertension and severe cardiomyopathic changes in different extremes. One case was dilated cardiomyopathy with heart failure, and the other showed echocardiographic features simulating hypertrophic obstructive cardiomyopathy. Both girls had high levels of urine catecholamines on presentation. Anthracycline group of chemotherapy was avoided. Chemotherapy and tumor resection resulted in successful normalization of blood pressure and regression of cardiomyopathic changes. Blood pressure and cardiomyopathic changes should be monitored not only at presentation, but also during the treatment for neuroblastoma.
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Kwok et al. (2013) conducted a case report in Neuroblastoma associated with hypertension and cardiomyopathy (n=2). Chemotherapy and tumor resection was evaluated on Normalization of blood pressure and regression of cardiomyopathic changes. Chemotherapy and tumor resection resulted in successful normalization of blood pressure and regression of cardiomyopathic changes in two girls with neuroblastoma.
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