Key result
Neuroblastoma treatment completely reverses severe infant heart failure, suggesting catecholamine-induced cardiac dysfunction.
Why the study?
Acute cardiac dysfunctions associated with neuroblastoma are rarely reported and their mechanisms remain unclear.
Case Report (n=1)
This case highlights that neuroblastoma can present with severe acute cardiac failure and dilated cardiomyopathy, mimicking Tako-Tsubo syndrome, which is reversible with specific treatment.
Alerts clinicians to neuroblastoma in unexplained infant cardiomyopathy; leaves open prevalence and mechanisms in pediatrics.
Acute cardiac dysfunctions associated to neuroblastoma have rarely been reported. Cases already described are mainly related to high blood pressure, and rarely to an "acute catecholamine cardiomyopathy" more frequently found in adults with pheochromocytoma or secreting paraganglioma. We here report a case of an 8-month-old infant with severe acute cardiac failure with dilated cardiomyopathy and moderate ischemic myocardial signs, revealing a favorable histoprognosis neuroblastoma. After specific treatment, evolution was favorable, and cardiac function completely recovered. The association of reversible ischemic signs with high plasmatic level of catecholamines suggests the existence of a catecholamine-induced acute cardiac dysfunction which imitates a Tako-Tsubo syndrome in neuroblastoma.
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Bénazé et al. (2016) conducted a case report in Dilated cardiomyopathy and neuroblastoma (n=1). Specific treatment for neuroblastoma was evaluated on Cardiac function recovery. Specific treatment of a neuroblastoma in an 8-month-old infant with severe acute cardiac failure led to complete recovery of cardiac function, suggesting a catecholamine-induced acute cardiac dysfunction.
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