Key result
Review synthesizes core cardiovascular physiology and mechanisms of targeted therapies for myocardial ischemia.
Why the study?
Effective methods to increase energy output of ischemic myocardial cells have yet to be developed, motivating exploration of novel approaches.
Does not alter MI management; leaves open whether reptilian anaerobic metabolism can inform future therapies.
Will further study of our reptilian kindred (whose hearts demonstrate a unique anaerobic metabolic capacity) yield a treatment for myocardial infarction? Possibly, suggests one of the contributors toClinical Cardiovascular Physiology. He cites many approaches to the problem of inadequate myocardial oxygenation, including experimental attempts to increase glycolytic flux, enhance excitation-contraction coupling, and improve coronary blood flow. Unfortunately, methods that can effectively increase the energy output of the ischemic myocardial cell have yet to be developed. However, reducing the work load of the ischemic heart (with propranolol, furosamide, or nitroglycerine and nitroprusside) helps balance energy demand and supply. Although they consider the role of the digitalis glucosides and other treatment, Dr Levine and the 39 contributors to his book mostly present their concepts of normal and abnormal cardiac physiology. They also take up the effects of disordered cardiac function on the kidneys and lungs, often in much detail. Schreiner and
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Harry B. Greenberg (1976) conducted a review in Myocardial infarction and disordered cardiac function. Clinical Cardiovascular Physiology presents concepts of normal and abnormal cardiac physiology, exploring treatments for inadequate myocardial oxygenation and systemic effects of disordered function.
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