Botulinum toxin was given in large intravenous doses to 7- and 12- day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest that neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.
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Daniel B. Drachman (1964) studied this question.
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