The crystal structure determination of the anhydrous form of any organic compound has been a challenge because of solvent incorporation during crystallization. A device to grow anhydrous forms of low melting organic solids based on vaporization and condensation by a gradient cooling technique has been designed. Its utility has been evaluated by growing anhydrous forms of ciprofloxacin, midazolam, and ofloxacin. Ciprofloxacin crystallizes in triclinic P 1̅, midazolam in monoclinic P 2 1 / n, and ofloxacin in the C 2/ c space group. Comparative studies on the conformational features with solvated structure show no significant variation in the aromatic moieties.
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Mahapatra et al. (2010) studied this question.
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