Key result
Severe hypocalcemia and hypomagnesemia from untreated endocrinopathies trigger marked QTc prolongation and cardiac arrest.
Why the study?
Acquired long QT syndrome caused by electrolyte imbalance and endocrine disorders is life-threatening and requires careful monitoring and management to prevent malignant arrhythmias and cardiac arrest.
Case Report (n=1)
Warrants electrolyte screening in hypoparathyroidism and hypothyroidism to avert QT-related arrest; single case leaves open broader applicability.
Long QT syndrome (LQTS) is the prolongation of QT interval in the electrocardiogram; it is usually classified as congenital or acquired. It is a life-threatening condition that could lead to malignant ventricular arrhythmias and sudden cardiac arrest. The most common causes for Acquired Long QT syndrome are medications like anti-arrhythmic, electrolyte imbalance, or endocrine disorders. Therefore, any patient having one of these conditions should be monitored carefully to prevent deleterious consequences. The central management for acquired LQTS is the correction of the underlying cause. However, recent studies showed that implantable cardioverter-defibrillator (ICD) could be helpful in the secondary prevention of such patients. Here we report a case of cardiac arrest due to acquired prolonged QT interval secondary to endocrine disorder and electrolytes imbalance.
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Muneera AlTaweel (2023) conducted a case report in Acquired Long QT Syndrome and Cardiac Arrest (n=1). Electrolyte imbalance (hypocalcemia and hypomagnesemia) was evaluated on Cardiac arrest and QTc prolongation. Severe electrolyte imbalances including hypocalcemia and hypomagnesemia secondary to hypoparathyroidism and under-replaced hypothyroidism resulted in an acquired prolonged QT interval and cardiac arrest.
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