The relationship between oral burns and oral squamous cell carcinoma: a systematic review

Background: Micro-RNAs (miRNAs) have been found to play crucial roles in various biological processes and have been implicated in the development and progression of many diseases, including cancer. In recent years, several studies have suggested that miRNA may have a potential role in the relationship between oral burns and various. This systematic review aims to summarize the current evidence on the roles of miRNA in the relationship between oral burns and oral squamous cell carcinoma (OSCC). Materials and methods: The present systematic review was performed using PubMed, Google Scholar, Science Direct, ProQuest, Ovid, and Embase from April 2024 to May 2024 following the "Preferred Reporting Items for Systematic Reviews" guidelines. The keywords, including "oral burn OR burning tongue OR burning mouth" AND "Oral squamous cell carcinoma" AND "miRNA." Results: The study reviewed 9 publications, examining miRNA interactions common to oral burns and cancers. Among them, 5 studies focused on various burn types, while 4 addressed oral malignancies. Synthesizing these findings identified 5 shared miRNAs between burns and oral cancers. Regarding burn types, thermal burns were most mentioned, followed by carbon dioxide laser and chemical burns. For cancer, oral squamous cell carcinoma was predominant, with one study on tongue squamous cell carcinoma. Noteworthy miRNAs include hsa-miR-205, hsa-miR-18a, hsa-mir-23b, hsa-mir-203, and hsa-mir-150, each exhibiting distinct roles and expression patterns in burns and carcinogenesis. Conclusion: Overall, the findings of this systematic review highlight the potential importance of miRNA in the relationship between oral burns and OSCC.